Progressive Care Nursing Certification (PCCN) Practice Exam

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What is a potential side effect of administering milrinone?

Thrombocytopenia
Ventricular dysrhythmias
Hyperkalemia
Increased urination

The correct answer is: Ventricular dysrhythmias

Administering milrinone, a phosphodiesterase inhibitor, can lead to an increased risk of ventricular dysrhythmias. This is significant due to the drug's mechanism of action, which enhances myocardial contractility and causes vasodilation. While these effects are beneficial for patients with heart failure, they can also lead to increased calcium availability in cardiac myocytes, which might precipitate dysrhythmias. Additionally, monitoring for changes in heart rhythm is essential during milrinone therapy, particularly in patients with pre-existing cardiac conditions or those on other medications that also affect cardiac rhythm. Understanding the potential for ventricular dysrhythmias emphasizes the importance of careful patient monitoring and assessment following administration of this medication.