Progressive Care Nursing Certification (PCCN) Practice Exam

What is the antidote for acute liver failure caused by acetaminophen overdose?

1. Hemodialysis

2. Acetylcysteine (Acetadote)

3. Fluid resuscitation

4. There is no antidote for acetaminophen overdose

The correct answer is: Acetylcysteine (Acetadote)

The antidote for acute liver failure caused by acetaminophen overdose is Acetylcysteine, commonly referred to by its brand name, Acetadote. Acetylcysteine works by replenishing glutathione stores in the liver, which are depleted during an acetaminophen overdose. This process helps to neutralize the toxic metabolite associated with acetaminophen, thereby preventing liver damage and facilitating the safe excretion of the byproducts. Administering Acetylcysteine is particularly effective when given within 8 to 10 hours of the overdose; however, it can still provide benefits even when given later. The treatment can be delivered orally or intravenously, making it versatile for different clinical scenarios. In contrast, strategies such as hemodialysis or fluid resuscitation may be utilized in managing kidney damage or overall stabilization of the patient but do not specifically counteract the toxic effects of acetaminophen. Furthermore, while there is no other specific antidote to replace Acetylcysteine in this context, it is crucial for healthcare providers to act swiftly upon suspecting an overdose to administer the appropriate antidote effectively.